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it significantly influences disease severity, chronic inflammation, and tissue pathology

These results demonstrate that inhibiting ferroptosis, rather than activating the AMPK pathway, is the primary mechanism of action of metformin against IIRI

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J Neurosci Methods 58:6175 Bishop GM, Dringen R, Robinson SR (2007) Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes

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